VISDB Viral Integration Site DataBase

VIS ID

TVIS10012731

Fusion event

HBV-TMEM65 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

2020

Orient

+

Integrated sequence

AAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGG| |AAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGG

Chromosome

chr8

Cytoband

q24.13

Reference genome

Start

End

125367151/124354910 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

FRA8C ; FRA8E

Target gene

miRNAs that regulate target gene

hsa-mir-33a-5p ; hsa-let-7b-5p ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4768-3p ; hsa-mir-4733-5p ; hsa-mir-4695-5p ; hsa-mir-6736-5p ; hsa-mir-4701-3p ; hsa-mir-1262 ; hsa-mir-489-3p ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-661 ; hsa-mir-3913-3p ; hsa-mir-6776-5p ; hsa-mir-766-3p ; hsa-mir-6742-3p ; hsa-mir-6849-3p ; hsa-mir-508-5p ; hsa-mir-4432 ; hsa-mir-1254 ; hsa-mir-1273g-3p ; hsa-mir-3116 ; hsa-mir-3613-3p ; hsa-mir-3690 ; hsa-mir-371a-5p ; hsa-mir-371b-5p ; hsa-mir-372-5p ; hsa-mir-373-5p ; hsa-mir-451b ; hsa-mir-4638-3p ; hsa-mir-4668-5p ; hsa-mir-4696 ; hsa-mir-4793-3p ; hsa-mir-616-5p ; hsa-mir-6501-3p ; hsa-mir-7703

Nearest miRNA

hsa-mir-12123/Upstream/1006780; hsa-mir-10400/Downstream/153605;

Nearest TSS

Nearest CpG islands

None/Target, chr8-CpG: 109/Upstream/53054, chr8-CpG: 132/Downstream/16666

Upstream sequence

AGTTTAGCTCATTTACGCCTATTTCTGATTTAAGTCAAGGAGAATTCAAATAATGGTaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaCCCCAAAAAAAA

Downstream sequence

AAGTTTGTtgtgccatacttgaaactcttctgtaaatttaagactgtttcaaaatgtaaaaagGAATAAAAAAATTCGGTGGGAAAAACACAGGAGAACA