Basic Information
VIS ID
TVIS10012732
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2288
Orient
+
Integrated sequence
AGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCC| |TCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCG
Host Sequence
Chromosome
chr8
Cytoband
q24.21
Reference genome
GRCh37/hg19
Start
128222786/127210541 (Hg38)
End
128222786/127210541 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA8C ; FRA8E
Target gene
CCAT1 ; LOC108353813
Nearest miRNA
hsa-mir-12123/Upstream/2388483; hsa-mir-10400/Downstream/585421;
Nearest TSS
ENST00000518652/Upstream/130667; ENST00000642795/Downstream/34096;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/652016, chr8-CpG: 29/Downstream/105101
Nearby gene
PCAT1(-189527) ; POU5F1B(+205071) ;
Upstream sequence
caggtggatatttggctagctttgaggatttcgttggaaacggtaatgtcttcaaagaaaatctagacagaaacatcctcagaaacatcttcgtgatgtt
Downstream sequence
AGTAGCAGGTGATGGGTTATGATGTCAGTTTTGGAACCGGACAACTAAGGCCCAAAGGTGTTCAGGCATCCTCTTCTGGTCCAAAGGTCAGCTCCAGGGA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate