Basic Information
VIS ID
TVIS10012736
Fusion event
HBV-LOC105379365 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1918
Orient
+
Integrated sequence
CAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTT| |ATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCG
Host Sequence
Chromosome
chr8
Cytoband
p12
Reference genome
GRCh37/hg19
Start
34076746/34219228 (Hg38)
End
34076746/34219228 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105379365
Nearest miRNA
hsa-mir-124-1/Upstream/4261880; hsa-mir-10400/Downstream/7051820;
Nearest TSS
ENST00000518652/Upstream/44342; ENST00000522460/Downstream/9211;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/496146, chr8-CpG: 103/Downstream/1015933
Nearby gene
DUSP26(-619307) ; UNC5D(+1016229) ;
Upstream sequence
aacttctttgtggtgtctgcattcaagtcacagaactgaacatcccctcacatagagcagttgtgcagcactctatttgtagtatctcgaagtggacatt
Downstream sequence
tacaaaatcaatgtgcaaaaatcacaagcattcttatacaccaataacagacaaacaaagagccaaatcatgagtgaactcccattcacaattgcttcaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate