Basic Information
VIS ID
TVIS10012745
Fusion event
HBV-WHRN integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1877
Orient
+
Integrated sequence
GGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAA| |GCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCT
Host Sequence
Chromosome
chr9
Cytoband
q32
Reference genome
GRCh37/hg19
Start
117213242/114450962 (Hg38)
End
117213242/114450962 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA9E
Target gene
WHRN
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-let-7a-1/Upstream/241433; hsa-mir-12126/Downstream/5794017;
Nearest TSS
ENST00000422679/Upstream/24891; ENST00000473413/Downstream/52211;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/52178, chr9-CpG: 165/Downstream/53226
Upstream sequence
atcaaggatatagagaaattggaacccttcttcactgctggagggaatggaaaatggtgtagccgttatgaaaaacagtacggaggtttctcaaaaatta
Downstream sequence
CCCCTTTTCTGCCCCATGGCAGACACAGCGCTAAGTGACTCTTAGCATTAGCTAACTATCCCTTCTTGCAGAGCCCGGCTGCAACCACACAGGTACAAAC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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