Basic Information
VIS ID
TVIS10012748
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1816
Orient
+
Integrated sequence
CTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCA| |TGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCC
Host Sequence
Chromosome
chrX
Cytoband
p11.23
Reference genome
GRCh37/hg19
Start
48136205/48276770 (Hg38)
End
48136205/48276770 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC100420551 ; SSXP8
Nearest miRNA
hsa-mir-1587/Upstream/689265; hsa-let-7f-2/Downstream/1726378;
Nearest TSS
ENST00000429181/Upstream/21453; ENST00000620320/Downstream/57669;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/204994, chrX-CpG: 80/Downstream/199071
Nearby gene
SSX1(-9326) ; SSX3(+69658) ;
Upstream sequence
aattgaaatatccattaccccaaacacttatcatttctttgtgttgggaacaatccaaatattctcttctagctattttgaaatataaaataaattattg
Downstream sequence
TACACATGAAAGGTGGGAGGGTTGCCTTGAAACCTAGAAAGAAGCAAAATGTTTATTCCTTAAGAGACAAGCTTGGGCCTGGTATGGTGGCTCATGTCTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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