Basic Information
VIS ID
TVIS10012751
Fusion event
HBV-chrY integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1797
Orient
-
Integrated sequence
TTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATT| |GGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTT
Host Sequence
Chromosome
chrY
Cytoband
q11.23
Reference genome
GRCh37/hg19
Start
27179197/25033050 (Hg38)
End
27179197/25033050 (Hg38)
Orient
-
Location type
Intronic
Target gene
BPY2 ; BPY2B ; BPY2C
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-335-5p ; hsa-mir-335-5p
Nearest miRNA
hsa-mir-12120/Upstream/11553784;
Nearest TSS
ENST00000430575/Upstream/198923; ENST00000361963/Downstream/10973;
Nearest CpG islands
None/Target, chrY-CpG: 62/Upstream/198472, chrY-CpG: 51/Downstream/431320
Upstream sequence
taatgctatccctccccagccccgcatcccaccaaccaccccatgtgtggtgttccccaccctgtgtccctgtgttcttattgttcaactcctacttatg
Downstream sequence
ttacatcaccttggttcaggtttcactttcatgtcacaatgctctatgtgtgtgaggccaaagcatttagtcccataaactagtttattggcccaagaga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate