Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10012757
Fusion event
HBV-VRK3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
Polymerase|
Start
1169
Orient
+
Integrated sequence
ATGTATTCAATCTAAGCAGGCTTTCACTTTCTCGCCAACTTACAAGGCCTTTCTGTGTAAACAATACCTGAACCTTTACCCCGTTGCCCGGCAACGGCCA| |GGTCTGTGCCAAGTGTTTGCTGACGCAACCCCCACTGGCTGGGGCTTGGTCATGGGCCATCAGCGCATGCGTGGAACCTTTTCGGCTCCTCTGCCGATCC
Host Sequence
Chromosome
chr19
Cytoband
q13.33
Reference genome
Start
End
50491435/49988178 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
Target gene
Nearest miRNA
hsa-mir-10395/Upstream/55041; hsa-let-7e/Downstream/1218751;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/58297, chr19-CpG: 100/Downstream/36741
Upstream sequence
cataaggtagtagctagtaggagaccatctcatggagcaggacactgaggctcgcagacgttaacaccccacagtggtggtgccagagtctgagcccagg
Downstream sequence
cagtgtggctccggaacacctgcCTCGCCTGCTGTGTGGACACTGCAGCACATGCCTGTGCGGCTCAGAGGACTTGGGCTCTGCTGGATGCCACCTCCCC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.