Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10012758
Fusion event
HBV-VRK3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
Polymerase|
Start
1179
Orient
+
Integrated sequence
TCTAAGCAGGCTTTCACTTTCTCGCCAACTTACAAGGCCTTTCTGTGTAAACAATACCTGAACCTTTACCCCGTTGCCCGGCAACGGCCAGGTCTGTGCC| |AAGTGTTTGCTGACGCAACCCCCACTGGCTGGGGCTTGGTCATGGGCCATCAGCGCATGCGTGGAACCTTTTCGGCTCCTCTGCCGATCCATACTGCGGA
Host Sequence
Chromosome
chr19
Cytoband
q13.33
Reference genome
Start
End
50491540/49988283 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
Target gene
Nearest miRNA
hsa-mir-10395/Upstream/55146; hsa-let-7e/Downstream/1218646;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/58402, chr19-CpG: 100/Downstream/36636
Upstream sequence
tggctccggaacacctgcCTCGCCTGCTGTGTGGACACTGCAGCACATGCCTGTGCGGCTCAGAGGACTTGGGCTCTGCTGGATGCCACCTCCCCTTCCC
Downstream sequence
TCCTGCTCCCAGTTGGGCTCTGGGCTTCTGTCCACCTGCAGGGGTTCTGCTGACCACCTGCAGGGGTTCTGCTGACCCCTAGACTCACTTCTGTTTTTGC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.