Basic Information
VIS ID
TVIS10012760
Fusion event
HBV-LOC107985792 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1144
Orient
+
Integrated sequence
ATCCTGCGTTGATGCCTTTGTATGCATGTATTCAATCTAAGCAGGCTTTCACTTTCTCGCCAACTTACAAGGCCTTTCTGTGTAAACAATACCTGAACCT| |TTACCCCGTTGCCCGGCAACGGCCAGGTCTGTGCCAAGTGTTTGCTGACGCAACCCCCACTGGCTGGGGCTTGGTCATGGGCCATCAGCGCATGCGTGGA
Host Sequence
Chromosome
chr2
Cytoband
p24.1
Reference genome
GRCh37/hg19
Start
23374360/23151489 (Hg38)
End
23374360/23151489 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC107985792
Nearest miRNA
hsa-mir-3125/Upstream/3802984; hsa-mir-10b/Downstream/2177151;
Nearest TSS
ENST00000437798/Upstream/60652; ENST00000415245/Downstream/47567;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/2107400, chr2-CpG: 256/Downstream/233369
Nearby gene
LINC01822(-1440836) ; KLHL29(+233938) ;
Upstream sequence
AATTTCCTGGACTGAGAGATAAGCAAGGTCCAACTTAGTGATGTGTGTCGGGATTCTGCTATTCTGTGAGAGATGGAGATAAATTCTCCCATAGCTCTAA
Downstream sequence
CTTGAGAATATGTGCTAGCAACTTCTGCAAGTTAAAAAGTATCTTCTTCCCTACTGGAATGTTACCTTTGCTTAATGGAAATAAGAAACGTTCTATCAAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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