FIP1L1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10012762
Fusion event
HBV-FIP1L1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1833
Orient
+
Integrated sequence
GGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTC| |TGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAG
Host Sequence
Chromosome
chr4
Cytoband
q12
Reference genome
GRCh37/hg19
Start
54319376/53453209 (Hg38)
End
54319376/53453209 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA4B
Target gene
FIP1L1
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-877-3p
Nearest miRNA
hsa-mir-12113/Upstream/740462; hsa-mir-1243/Downstream/7469410;
Nearest TSS
ENST00000502981/Upstream/10956; ENST00000507206/Downstream/5342;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/74979, chr4-CpG: 82/Downstream/610865
Nearest cancer related gene
FIP1L1(OG, No orient, 0)
Upstream sequence
ctcttcttgcccactaccatgtaaaaagtctgtttgttctccctttatctttgccatgattgtgaggcctccccagccatgtggaactgtgattaaatta
Downstream sequence
ATTTCAGTTCACTTGGAAAAGAGATGCTCAGGGAGTACATAGGAAAGCCATCTTAAAATGATAAAGGATTAGAGGCTTCCCATTACCTTGAAcagtagtc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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