Basic Information
VIS ID
TVIS10012764
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
130
Orient
-
Integrated sequence
GATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCT| |CGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAAT
Host Sequence
Chromosome
chr7
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
53205316/53137623 (Hg38)
End
53205316/53137623 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1183/Upstream/8255823; hsa-mir-10399/Downstream/3818162;
Nearest TSS
ENST00000635602/Upstream/101981; ENST00000629899/Downstream/379493;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/101357, chr7-CpG: 21/Downstream/49666
Nearby gene
POM121L12(-100698) ; LINC01446(+517886) ;
Upstream sequence
TTTCCCTGCTGAAATGAAGTACAAAACTGTGTCCTTTGAGTGTAGATTATGTGCAGGGCTACTGTCAGACTGTACTGGATAACATCTGAAGGATGAATAA
Downstream sequence
tcatatgtgcctttatatttattctagtctATATTTATATCACTGAGTAAATATATAGGAATGTAGATACATATAGCTATAGTTATAGATACAAATATAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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