Basic Information
VIS ID
TVIS10012765
Fusion event
HBV-RNU2-42P integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1642
Orient
+
Integrated sequence
CGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTG| |CCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGT
Host Sequence
Chromosome
chr10
Cytoband
q26.2
Reference genome
GRCh37/hg19
Start
127579232/125890663 (Hg38)
End
127579232/125890663 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10F ; FRA10A ; FRA10B
Target gene
RNU2-42P
Nearest miRNA
hsa-mir-107/Upstream/70841; hsa-mir-202/Downstream/3952636;
Nearest TSS
ENST00000439456/Upstream/9348; ENST00000494896/Downstream/5773;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/67035, chr10-CpG: 152/Downstream/5017
Nearby gene
DHX32(-9348) ; FANK1(+5876) ;
Upstream sequence
TGTTGGTTCATATCAGATACAACCAGCCTTGTATTGACAATTGGTTGAATATACAatattatattaataacaacagatactacagttgatcttagccaaa
Downstream sequence
aggccgagaagtgatGAATATACAGTATTGAATATTGTATTGCATATTGGTTGAATAACCAACCCTGCACAATCAAATTTTTTAAAAAGAATCCTTACAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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