VISDB Viral Integration Site DataBase

VIS ID

TVIS10012768

Fusion event

HBV-VWCE integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|large S protein|middle S protein|

Start

95

Orient

+

Integrated sequence

AATTCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGT| |TCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTC

Chromosome

chr11

Cytoband

q12.2

Reference genome

Start

End

61046969/61279497 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-371a-5p ; hsa-mir-371b-5p ; hsa-mir-372-5p ; hsa-mir-373-5p ; hsa-mir-5088-3p ; hsa-mir-513c-5p ; hsa-mir-514b-5p ; hsa-mir-5588-3p ; hsa-mir-616-5p ; hsa-mir-6807-5p

Nearest miRNA

hsa-mir-129-2/Upstream/1070341; hsa-let-7a-2/Downstream/229099;

Nearest TSS

Nearest CpG islands

None/Target, chr11-CpG: 30/Upstream/117707, chr11-CpG: 25/Downstream/2124

Upstream sequence

tgttgccaataaaaaaaaagtacaaaaattagccaggcttggtggtgggtggctataatcccagctacttgggaggattgcttaaaccctagaggcggag

Downstream sequence

gctgcagtgagccgagatcacaccactgcactccagcctgggtgacagagcaagactccatctcaaaaaaaaacaaaaacaaaaaaacaaaaaaAAACCA