Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10012772
Fusion event
HBV-PPFIA2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
636
Orient
-
Integrated sequence
TGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAA| |TTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAG
Host Sequence
Chromosome
chr12
Cytoband
q21.31
Reference genome
Start
End
82123746/81729967 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-let-7i/Upstream/571506; hsa-mir-1178/Downstream/5015101;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/651627, chr12-CpG: 34/Downstream/28574
Upstream sequence
gccagtaagaaagctgggacttcagttccacaaccgcaaggattgaattcagccaacaagtggaatgagcttggaaagggatttgtccccagaactgtca
Downstream sequence
gaaaagaatgtagcctttgctgacaccttaattttagctctgtgagagtctaagcaaaagacccagttggctcaaggtctacctgaacttctgacccaca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.