Basic Information
VIS ID
TVIS10012775
Fusion event
HBV-chr16 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2095
Orient
-
Integrated sequence
GATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAAC| |TAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAG
Host Sequence
Chromosome
chr16
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
199158/149159 (Hg38)
End
199158/149159 (Hg38)
Orient
-
Location type
Intronic
Target gene
HBA-LCR ; HBZ
Nearest miRNA
hsa-mir-6859-4/Upstream/132040; hsa-mir-11401/Downstream/386157;
Nearest TSS
ENST00000527434/Upstream/10299; ENST00000252951/Downstream/3528;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/10254, chr16-CpG: 96/Downstream/4595
Nearby gene
NPRL3(-10461) ; HBZ(+3696) ;
Upstream sequence
CCACATCCCCTCCTCATGGGCCCATGTGCCCAAGGTGCCCCTAGGTGCCAGGCTGAGATGAACCAGGAGTGTCCTTCTGAACCCAGCAACAGCGAAGGGT
Downstream sequence
GACCAGGGAGGGCCAGTTCATCTCGGTCTGAAAGAAGCCCCAGATGAGCAAAGGATACACTGGCCTCCTGCGGTCAGCAGCACTTCCCAGGACAGTGAGC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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