VISDB Viral Integration Site DataBase

VIS ID

TVIS10012782

Fusion event

HBV-ZNF345 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

286

Orient

-

Integrated sequence

CCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGG| |GAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCT

Chromosome

chr19

Cytoband

q13.12

Reference genome

Start

End

37359079/36868177 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-548s ; hsa-mir-3926 ; hsa-mir-3190-5p ; hsa-mir-520f-5p ; hsa-mir-8073 ; hsa-mir-221-5p ; hsa-mir-4793-5p ; hsa-mir-6771-3p ; hsa-mir-3675-3p

Nearest miRNA

hsa-mir-10395/Upstream/1522550; hsa-let-7e/Downstream/2541446;

Nearest TSS

Nearest CpG islands

None/Target, chr19-CpG: 112/Upstream/17079, chr19-CpG: 48/Downstream/47852

Upstream sequence

ctgcaacctctgcttcctgcgttccaaaaattctcctgcctcaggctcccgagtagctgggattacaggtgcgtgccaccacgcccagctaatttttttt

Downstream sequence

acttttagtagagacagggttttaccacattggccaagctagtctcaaactcctgaccttgtgatccacccgccttggcctcccaaagtgctgggattac