Basic Information
VIS ID
TVIS10012794
Fusion event
HBV-chr20 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1826
Orient
-
Integrated sequence
AAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTT| |TCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAA
Host Sequence
Chromosome
chr20
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
50601379/51984840 (Hg38)
End
50601379/51984840 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-103a-2/Upstream/531863; hsa-mir-1-1/Downstream/2083568;
Nearest TSS
ENST00000382410/Upstream/121928; ENST00000454600/Downstream/113626;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/182334, chr20-CpG: 35/Downstream/99886
Nearby gene
SALL4(-182331) ; ZFP64(+99171) ;
Nearest cancer related gene
SALL4(OG, -182331) ;
Upstream sequence
AATTTACTGTCTGTGAGAGTTCTCTTCTATTTCAATTTTAGGGCTAAAGAATGTGGTTTTTTTTCCCTCCAGGCAAATGAGattaaataaatatttaaat
Downstream sequence
tttGTGTGAAGTTTATTTAACATTTTCCACTCTTTGCTATTGCTTAAGTGCAAAGTTTTGTCTTTTTTTAAACATTATAATTGCTACTTAGAATTCTAAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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