Basic Information
VIS ID
TVIS10012798
Fusion event
HBV-chr22 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1749
Orient
-
Integrated sequence
TCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGA| |GGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTT
Host Sequence
Chromosome
chr22
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
21810167/21455878 (Hg38)
End
21810167/21455878 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1286/Upstream/421606; hsa-let-7a-3/Downstream/197103;
Nearest TSS
ENST00000624155/Upstream/13418; ENST00000545656/Downstream/10545;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/9115, chr22-CpG: 201/Downstream/11404
Nearby gene
HIC2(-4417) ; TMEM191C(+11292) ;
Upstream sequence
CTCTCCCTGCAGTGCCAGGCTGCGTCCTTTCCCACGCAAAGGCTAGCCTCTGTGCTGTGGAGACCAGACGGGAGGCTGGAGGGCCTTGGTGGCAGTGTAA
Downstream sequence
GAGGCTGGGCCACCAGCAGGGCCCAGGTGTCTTTCTCAGTGCGCCTGGTGCTACCAAGAACCGTGCCCTGGGCAGATGGCTGAGGAGCGCTCACCTGTCC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate