Basic Information
VIS ID
TVIS10012800
Fusion event
HBV-LINC02008 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
20
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCA| |AACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCG
Host Sequence
Chromosome
chr3
Cytoband
p12.2
Reference genome
GRCh37/hg19
Start
82496340/82447189 (Hg38)
End
82496340/82447189 (Hg38)
Orient
-
Location type
Intronic
Target gene
LINC02008
Nearest miRNA
hsa-let-7g/Upstream/2939220; hsa-mir-12124/Downstream/2938521;
Nearest TSS
ENST00000440867/Upstream/461037; ENST00000488348/Downstream/2422386;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/685387, chr3-CpG: 21/Downstream/360644
Nearby gene
GBE1(-685390) ;
Upstream sequence
ttgacaagggtgccaagtccattcaatgggaaaacaattgtctttttgacaaattatgccagaacaactcgacatccacatgtaaaagaatgaatttgaa
Downstream sequence
ATTTCTATTTATAGTCTTAGAGAAAAGAGAGCTTTTCTCTCTGTTAACATACCCTTAAACCCTGATTTGGCTTACCTCAATTGAGCCATATTCTCATCTC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate