Basic Information
VIS ID
TVIS10012803
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2161
Orient
-
Integrated sequence
GCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCA| |GTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGT
Host Sequence
Chromosome
chr5
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
114387514/115051817 (Hg38)
End
114387514/115051817 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10397/Upstream/4537902; hsa-mir-103a-1/Downstream/1203926;
Nearest TSS
ENST00000502646/Upstream/19923; ENST00000514544/Downstream/36658;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/688319, chr5-CpG: 160/Downstream/117303
Nearby gene
KCNN2(-555317) ; TRIM36(+72945) ;
Upstream sequence
ttttggaataggtatggtgtggtgctgaaaaaaatgtatattctgttgatttggggtgtagagctctgtagatgtctattatgtctgcttggtgcagagc
Downstream sequence
taataacttactattatacggatgttgtaaggattaagtgagatagtatgtgcaaagcacttacaaaatgcttggtatagagtaggccttaaatagtata
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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