Basic Information
VIS ID
TVIS10012805
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1814
Orient
-
Integrated sequence
GACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCAC| |CATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGAC
Host Sequence
Chromosome
chr5
Cytoband
p14.1
Reference genome
GRCh37/hg19
Start
25981304/25981195 (Hg38)
End
25981304/25981195 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA5E
Nearest miRNA
hsa-mir-10397/Upstream/8825203; hsa-mir-103a-1/Downstream/5954907;
Nearest TSS
ENST00000502646/Upstream/535270; ENST00000514255/Downstream/418624;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/71653, chr5-CpG: 28/Downstream/688244
Nearby gene
LINC02239(-1140612) ; CDH9(+899405) ;
Upstream sequence
tctggccccagccatctctccagcctcatttctgGTGACTCCCAGATCTGGCCCCAGCCATGTCTCTAGACTCCAAACTTATTCCTTATAATGCTCCCAC
Downstream sequence
ataccagggcctgttgaggggtggaagtgaggggagggaacctTTGTAACACTCTTACACAGCTAAATAATGGCCACCTATTAACTACATCACAGAATTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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