Basic Information
VIS ID
TVIS10012812
Fusion event
HBV-NME8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2443
Orient
+
Integrated sequence
GTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAAT| |CTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTT
Host Sequence
Chromosome
chr7
Cytoband
p14.1
Reference genome
GRCh37/hg19
Start
37910198/37870596 (Hg38)
End
37910198/37870596 (Hg38)
Orient
-
Location type
Intronic
Target gene
NME8
miRNAs that regulate target gene
hsa-mir-484
Nearest miRNA
hsa-mir-1183/Upstream/951164; hsa-mir-10399/Downstream/5280299;
Nearest TSS
ENST00000635602/Upstream/20343; ENST00000476435/Downstream/26221;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/421527, chr7-CpG: 82/Downstream/45424
Upstream sequence
atatcttcaaataaaaaccagacagaatcattctcagaaaattctttgtgatgtgtgcgttcaactcacatagtttaacctttcttttcatagagcagtt
Downstream sequence
aaaaaaaaaaaagtttaccaatttgtgttgggccacattcaaagccttcctgggcctcatgcagccagtgggctgcaggttggacaagcttggtctatag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate