VISDB Viral Integration Site DataBase

VIS ID

TVIS10012816

Fusion event

HBV-GTF2I integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|

Start

2652

Orient

+

Integrated sequence

TACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTTAATGAGAAAAGAAGATTGCAATTGATTATGCCTGCCAGGTT| |TTATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAACTAGACACTATTTA

Chromosome

chr7

Cytoband

q11.23

Reference genome

Start

End

74123362/74709031 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-let-7b-5p ; hsa-mir-21-5p ; hsa-mir-1229-3p ; hsa-mir-10a-3p ; hsa-mir-484 ; hsa-mir-23b-3p ; hsa-mir-99a-5p ; hsa-let-7e-5p ; hsa-let-7a-5p ; hsa-mir-335-3p ; hsa-mir-1305 ; hsa-mir-607 ; hsa-mir-3671 ; hsa-mir-580-5p ; hsa-mir-1252-3p ; hsa-mir-3646 ; hsa-mir-3121-3p

Nearest miRNA

hsa-mir-10525/Upstream/113005; hsa-mir-10399/Downstream/1206166;

Nearest TSS

Nearest CpG islands

None/Target, chr7-CpG: 39/Upstream/50279, chr7-CpG: 124/Downstream/78958

Upstream sequence

AAAAATCCTACCAGAAGAAGGGCTGACCATAGGAACTTGCCATTTCCTTGACCCCATCATATCTGAGGAAAAAACAACAGAAAAGGTAATTATATTATAC

Downstream sequence

ATTTGAGTAATCTCTAGTCTAATGGACAAATGGAAAGGAAACTTCCAGCCAAACTATTGTGAAATACTACCACACAGAAGAGAATAGttagtatatgcaa