Basic Information
VIS ID
TVIS10012821
Fusion event
HBV-HSFY1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1806
Orient
-
Integrated sequence
ACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGC| |ACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGG
Host Sequence
Chromosome
chrY
Cytoband
q11.222
Reference genome
GRCh37/hg19
Start
20717023/18555137 (Hg38)
End
20717023/18555137 (Hg38)
Orient
+
Location type
Intronic
Target gene
HSFY1
Nearest miRNA
hsa-mir-12120/Upstream/5075871;
Nearest TSS
ENST00000430575/Upstream/8417; ENST00000465253/Downstream/33575;
Nearest CpG islands
None/Target, chrY-CpG: 62/Upstream/167463, chrY-CpG: 61/Downstream/437580
Upstream sequence
cataggtatgtcagatatccccagtagcctgaacctagacaagggttacatcacttaggtgatcagcatagagatatgtgaaaattcccgtctagacaca
Downstream sequence
aaagaaactccatctcaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaCACAACAACAAAAAAAGAACGAAAAGAAAAAAAAAAGTTGCTGACTAGT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate