Basic Information
VIS ID
TVIS10012823
Fusion event
HBV-RBMY1D integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
939
Orient
-
Integrated sequence
CCTAACAAAACAAAGAGATGGGGTTACTCTCTAAATTTTATGGGTTATGTCATTGGATGTTATGGGTCCTTGCCACAAGAACACATCATACAAAAAATCA| |AAGAATGTTTTAGAAAACTTCCTATTAACAGGCCTATTGATTGGAAAGTATGTCAACGAATTGTGGGTCTTTTGGGTTTTGCTGCCCCTTTTACACAATG
Host Sequence
Chromosome
chrY
Cytoband
q11.223
Reference genome
GRCh37/hg19
Start
24017219/21871072 (Hg38)
End
24017219/21871072 (Hg38)
Orient
+
Location type
Intronic
Target gene
RBMY1D
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-5585-3p ; hsa-mir-570-3p ; hsa-mir-3121-5p
Nearest miRNA
hsa-mir-12120/Upstream/8391806;
Nearest TSS
ENST00000430575/Upstream/276406; ENST00000253848/Downstream/23367;
Nearest CpG islands
None/Target, chrY-CpG: 62/Upstream/336080, chrY-CpG: 29/Downstream/23340
Nearby gene
TTTY13(-260667) ; RBMY1D(+9004) ;
Upstream sequence
ccattctattccagtccattagtttcgactccattgcattcgagtgcattccattccgtggctgtccattccattccgtttgatgccattccatacgatt
Downstream sequence
agtgagaacatgcggtgcttggttttctgtccttgtgatagtgtgcttagtatgatggttttcagcttcatccatgaccttgcaaccacaaagagatacc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate