Basic Information
VIS ID
TVIS10012825
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2892
Orient
+
Integrated sequence
CAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTC| |CCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGG
Host Sequence
Chromosome
chr1
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
110288790/109746168 (Hg38)
End
110288790/109746168 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/147201; hsa-mir-11399/Downstream/2715602;
Nearest TSS
ENST00000473358/Upstream/5130; ENST00000453347/Downstream/5378;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/5484, chr1-CpG: 82/Downstream/164353
Nearby gene
GSTM3(-5130) ; EPS8L3(+3912) ;
Upstream sequence
tttccatgtagttgagcggttttgagtgagtttcttaatcctgagttctagtttggttgcactgtggtctgagagacagtttgttataatttctgttctt
Downstream sequence
ttacatttgctgaggagtgctttacttccaactatgtggtcaattttggaataggtgtggtgtggtgctgaaaaaaatgtatattctgttgatttggggt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate