Basic Information
VIS ID
TVIS10012826
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1802
Orient
-
Integrated sequence
GCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCT| |GCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGC
Host Sequence
Chromosome
chr1
Cytoband
p11.1
Reference genome
GRCh37/hg19
Start
121468211/121726413 (Hg38)
End
121468211/121726413 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/4631685; hsa-mir-1182/Downstream/24124174;
Nearest TSS
ENST00000473358/Upstream/145889; ENST00000443018/Downstream/21774099;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/206686, chr1-CpG: 312/Downstream/3359096
Nearby gene
EMBP1(-154525) ;
Upstream sequence
gcaatcatcacagagaagtttctgagaaggcttctgtctagattttatgtgaagatatacccgtttcgaacgaaggccacaaagtgctccaaatatccac
Downstream sequence
ttgcaggtcctccaaaaagagtgtttcaaacgtgaactaccaaaggaaggctcaactgtggactttgaatgccaacgtcagaaagatgtttctccgaaag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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