Basic Information
VIS ID
TVIS10012829
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2928
Orient
+
Integrated sequence
CTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACA| |CCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCACCCCACCGCA
Host Sequence
Chromosome
chr1
Cytoband
p35.2
Reference genome
GRCh37/hg19
Start
30968919/30496072 (Hg38)
End
30968919/30496072 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12136/Upstream/3941479; hsa-mir-101-1/Downstream/243084;
Nearest TSS
ENST00000473358/Upstream/80247; ENST00000414763/Downstream/220063;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/1017345, chr1-CpG: 101/Downstream/222053
Nearby gene
PTPRU(-1315594) ; MATN1(+215205) ;
Upstream sequence
ttagacagatcaatgagacagaaagttaacaaggatacccaggaattgaactcagctctgcagcaagcggacctaatagacatctacagaactctccacc
Downstream sequence
ccaaatcaacagaatatacatttttttcagcaccacaccacacctattccaaaattgaccacatagttggaagtaaagcactcctcagcaaatgtaaaag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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