Basic Information
VIS ID
TVIS10012831
Fusion event
HBV-LOC105378800 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2934
Orient
+
Integrated sequence
AACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAA| |ATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCACCCCACCGCACGGAGG
Host Sequence
Chromosome
chr1
Cytoband
p31.1
Reference genome
GRCh37/hg19
Start
73660103/73194420 (Hg38)
End
73660103/73194420 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1L
Target gene
LOC105378800
Nearest miRNA
hsa-mir-101-1/Upstream/2126704; hsa-mir-11399/Downstream/3865723;
Nearest TSS
ENST00000473358/Upstream/295280; ENST00000411903/Downstream/111750;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/910367, chr1-CpG: 24/Downstream/1003722
Nearby gene
NEGR1(-911826) ; LRRIQ3(+831599) ;
Upstream sequence
caacgagacagaaagttaacgaggatacccaggaattgaactcagctctgcaccaagtggacctaatagacatctacagaactctccaccccaaatcaac
Downstream sequence
agaatatacatttttttcagcaccacaccacacctattccaaaattgaccacatagttggaagtaaagcactcctcagcaaatgtaaaagaacaggaatt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate