Basic Information
VIS ID
TVIS10012835
Fusion event
HBV-LINC01725 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2876
Orient
+
Integrated sequence
TTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAAT| |CCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAG
Host Sequence
Chromosome
chr1
Cytoband
p31.1
Reference genome
GRCh37/hg19
Start
84153724/83688041 (Hg38)
End
84153724/83688041 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1L
Target gene
LINC01725
Nearest miRNA
hsa-mir-101-1/Upstream/6627839; hsa-mir-11399/Downstream/1445753;
Nearest TSS
ENST00000473358/Upstream/242074; ENST00000439186/Downstream/102239;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/1884678, chr1-CpG: 50/Downstream/172543
Nearby gene
LPHN2(-1695617) ; MIR548AP(+105874) ;
Upstream sequence
ttttggaataggtgtggtgtggtgctgaaaagaatgtatattctgttgatttggggtggagggttctgtagatgtctattatgtctgcttggtgcagagc
Downstream sequence
tgagttcaattcctggatatccttgttaactttcagtctcgttgatctgtctaatgctgacagtggggtgttaaagtctcccattattattgtgtgggag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate