Basic Information
VIS ID
TVIS10012837
Fusion event
HBV-DPYD-AS1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2876
Orient
+
Integrated sequence
TTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAAT| |CCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAG
Host Sequence
Chromosome
chr1
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
97784313/97318757 (Hg38)
End
97784313/97318757 (Hg38)
Orient
-
Location type
ncRNA_intronic
Fragile sites / regions
FRA1M
Target gene
DPYD-AS1
Nearest miRNA
hsa-mir-101-1/Upstream/2774978; hsa-mir-11399/Downstream/726485;
Nearest TSS
ENST00000473358/Upstream/53311; ENST00000431362/Downstream/402897;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/596494, chr1-CpG: 47/Downstream/601876
Upstream sequence
attagacagatcaacgagacagaaagtcaacaaggatacccaggaattgaactcagctctgcaccaagcggacctaatagacatctacagaactctccac
Downstream sequence
cccaaatcaacagaatatacatttttttcagcaccacaccacacctattccaaaattgaccacatagttggaagtaaagcactcctcagcaaatgtaaaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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