Basic Information
VIS ID
TVIS10012842
Fusion event
HBV-LOC105378305 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2906
Orient
+
Integrated sequence
TCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTG| |GATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCG
Host Sequence
Chromosome
chr10
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
54493557/52733797 (Hg38)
End
54493557/52733797 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10G
Target gene
LOC105378305
Nearest miRNA
hsa-mir-1265/Upstream/1434142; hsa-mir-107/Downstream/1874077;
Nearest TSS
ENST00000439456/Upstream/172692; ENST00000422842/Downstream/21612;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/322579, chr10-CpG: 18/Downstream/137654
Nearby gene
DKK1(-416140) ; MBL2(+31583) ;
Upstream sequence
gtttcttaatcctgagttctagtttgattgcactgtggtctgagagacagtttgttataatttctgttcttttacatttgctgaggagagctttacttcc
Downstream sequence
aactatgtggtcaattttggaataggcgtggtgtggtgctgaaaaaaatgtatattctgttgatttggggtggagagttctgtagatgtctattaggtct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate