DYNC2H1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10012848
Fusion event
HBV-DYNC2H1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2927
Orient
+
Integrated sequence
TCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAAC| |ACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCACCCCACCGC
Host Sequence
Chromosome
chr11
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
103010421/103139692 (Hg38)
End
103010421/103139692 (Hg38)
Orient
+
Location type
Intronic
Target gene
DYNC2H1
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-124-3p ; hsa-mir-331-3p ; hsa-mir-125b-5p ; hsa-let-7a-5p
Nearest miRNA
hsa-mir-10392/Upstream/1619787; hsa-let-7a-2/Downstream/710214;
Nearest TSS
ENST00000527297/Upstream/30117; ENST00000533027/Downstream/65219;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/47372, chr11-CpG: 43/Downstream/896985
Upstream sequence
tttctgttcttttacatttgctgaggagagctttacttccaactatgtggtcaattttggaataggtgtggtgtggtgttgaaaaaaatgtatattctgt
Downstream sequence
tgatctggggtggagagttctgtagatgtctattaggtccacttggtgcagagctgagttcaattcctgggtatccttgttaactttctgtctcgttgat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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