Basic Information
VIS ID
TVIS10012849
Fusion event
HBV-chr11 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2876
Orient
+
Integrated sequence
TTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAAT| |CCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAG
Host Sequence
Chromosome
chr11
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
103689072/103818344 (Hg38)
End
103689072/103818344 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10392/Upstream/2298439; hsa-let-7a-2/Downstream/31562;
Nearest TSS
ENST00000527297/Upstream/349955; ENST00000527804/Downstream/76927;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/726024, chr11-CpG: 43/Downstream/218333
Nearby gene
DYNC2H1(-338481) ; MIR4693(+31562) ;
Upstream sequence
ttttggaataggtgtggtgtggtgctgtaaagaatgtatattctgttgatttggggtggagaattctgtagatgtctattatgtctgcttggtgcagagc
Downstream sequence
tgagttcaattcctggatatccttgttaactttctgtcttgttggtctgtctaatgttgacagtggggtgtaaaagtctcccattattattgtgtgggag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate