VISDB Viral Integration Site DataBase

VIS ID

TVIS10012850

Fusion event

HBV-CASP5 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|large S protein|

Start

2881

Orient

+

Integrated sequence

TAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCT| |GGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCC

Chromosome

chr11

Cytoband

q22.3

Reference genome

Start

End

104889554/105018827 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-3611 ; hsa-mir-943 ; hsa-mir-4709-3p ; hsa-mir-4480 ; hsa-mir-6088 ; hsa-mir-1909-5p ; hsa-mir-4770 ; hsa-mir-143-3p

Nearest miRNA

hsa-mir-10392/Upstream/1168847; hsa-let-7a-2/Downstream/6328930;

Nearest TSS

Nearest CpG islands

None/Target, chr11-CpG: 30/Upstream/854497, chr11-CpG: 31/Downstream/591572

Nearest cancer related gene

CASP5(TSG, No orient, 0)

Upstream sequence

caacattagacagatcagcgagacagaaagtcaacaaggatacccaggaattgaactcagctctgcaccaagcggacctaatagacatctacagaactct

Downstream sequence

ccaccccaaatcaacagaatatacatttttttcagcaccacaccacacctattccaaaattgaccacatagttggaagtaaagcactcctcagcaaatgt