Basic Information
VIS ID
TVIS10012853
Fusion event
HBV-chr11 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2907
Orient
+
Integrated sequence
CATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGG| |ATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGG
Host Sequence
Chromosome
chr11
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
45147282/45125731 (Hg38)
End
45147282/45125731 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105376652 ; PRDM11
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-1184 ; hsa-mir-1205 ; hsa-mir-17-3p ; hsa-mir-3158-5p ; hsa-mir-544a
Nearest miRNA
hsa-mir-129-2/Upstream/1544248; hsa-let-7a-2/Downstream/565973;
Nearest TSS
ENST00000527297/Upstream/29925; ENST00000526442/Downstream/20944;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/168252, chr11-CpG: 116/Downstream/20756
Nearest cancer related gene
PRDM11(TSG, No orient, 0)
Upstream sequence
ccatgtagttgagcggttttgagtgagtttcttaatcctgagttctagtttgattgcactgtggtttgagagacagtttgttataatttctgttctttta
Downstream sequence
catttgctgaggagtgctttacttccaactatgtggtcaattttggaataggtgtggtgtggtgctgaaaaaaatgtatattctgttgatttggggtgga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate