Basic Information
VIS ID
TVIS10012854
Fusion event
HBV-LOC107984019 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2911
Orient
+
Integrated sequence
TTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCC| |AGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTG
Host Sequence
Chromosome
chr11
Cytoband
p15.4
Reference genome
GRCh37/hg19
Start
6928491/6907260 (Hg38)
End
6928491/6907260 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC107984019
Nearest miRNA
hsa-mir-210/Upstream/3051119; hsa-let-7a-2/Downstream/327506;
Nearest TSS
ENST00000527297/Upstream/14661; ENST00000317834/Downstream/13714;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/223548, chr11-CpG: 58/Downstream/19029
Nearby gene
OR2D2(-14760) ; OR2D3(+13742) ;
Upstream sequence
acagaaagttaacaacgatatccaggaattgaactcagctctgcaccaagcagacctaatagacatctacagaactctccaccccaaatcaacagaatat
Downstream sequence
acattattttcaacaccacaccacacctattccaaaattgaccacatagttggaagtaaagcactcctcagcaaatgtaaaagaacagaaattataacaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate