Basic Information
VIS ID
TVIS10012855
Fusion event
HBV-S100A11P3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2895
Orient
+
Integrated sequence
CACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCG| |ACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGC
Host Sequence
Chromosome
chr11
Cytoband
q13.4
Reference genome
GRCh37/hg19
Start
71224746/71513700 (Hg38)
End
71224746/71513700 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
S100A11P3
Nearest miRNA
hsa-mir-10392/Upstream/40132; hsa-let-7a-2/Downstream/558528;
Nearest TSS
ENST00000527297/Upstream/9836; ENST00000398536/Downstream/13567;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/60066, chr11-CpG: 27/Downstream/5241
Nearby gene
NADSYN1(-12165) ; KRTAP5-7(+13567) ;
Upstream sequence
cactgttaacattagacagatcaacgagacagaaagttaacaaggatacccaggaattgaactcagctctgcaccaagcagacctaatagacatctacag
Downstream sequence
aactctccaccccaaatcaacagaatatacatttttttcagcaccacaccacacctattccaaaattgaccacatagttggaagtaaagcactcctcagt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate