Basic Information
VIS ID
TVIS10012869
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2886
Orient
+
Integrated sequence
GAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGAT| |TCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAA
Host Sequence
Chromosome
chr12
Cytoband
q13.11
Reference genome
GRCh37/hg19
Start
48943997/48550214 (Hg38)
End
48943997/48550214 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA12A
Nearest miRNA
hsa-mir-1244-3/Upstream/417347; hsa-let-7i/Downstream/104230;
Nearest TSS
ENST00000382841/Upstream/24582; ENST00000328207/Downstream/9668;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/21868, chr12-CpG: 66/Downstream/131492
Nearby gene
OR8S1(-22111) ; LALBA(+17470) ;
Upstream sequence
gccttcatttcattatgtacccagtagtcattcaggagcaggttgttcagtttccatgtagttgagtggttttgagtgagtttcttaatcctgagttcta
Downstream sequence
gttgattgcactgtggtctgagagacagtttgttataatttctgttcttttacatttgctgaggagtgctttacttccaactatgtggtcaattttggaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate