VISDB Viral Integration Site DataBase

VIS ID

TVIS10012871

Fusion event

HBV-ACVR1B integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|Polymerase|

Start

1461

Orient

-

Integrated sequence

TATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGACC| |CTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCC

Chromosome

chr12

Cytoband

q13.13

Reference genome

Start

End

52354016/51960232 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-210-3p ; hsa-mir-24-3p ; hsa-mir-7-5p ; hsa-mir-182-5p ; hsa-mir-197-3p ; hsa-mir-26b-5p ; hsa-mir-15a-5p ; hsa-let-7c-5p ; hsa-let-7a-5p ; hsa-mir-371a-5p ; hsa-mir-3121-3p ; hsa-mir-4266 ; hsa-mir-4695-5p ; hsa-mir-4779 ; hsa-mir-6888-3p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106a-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-3609 ; hsa-mir-548ah-5p ; hsa-mir-4709-3p ; hsa-mir-4796-3p ; hsa-mir-5689 ; hsa-mir-3680-3p ; hsa-mir-199a-5p ; hsa-mir-135b-5p ; hsa-mir-541-5p ; hsa-mir-7106-5p ; hsa-mir-6739-5p ; hsa-mir-3153 ; hsa-mir-6733-5p ; hsa-mir-765 ; hsa-mir-4479 ; hsa-mir-4726-3p ; hsa-mir-6764-5p ; hsa-mir-1915-3p ; hsa-mir-6840-3p ; hsa-mir-6754-5p ; hsa-mir-7113-5p ; hsa-mir-4441 ; hsa-mir-4270 ; hsa-mir-6783-5p ; hsa-mir-4739 ; hsa-mir-4756-5p ; hsa-mir-1321 ; hsa-mir-518f-3p ; hsa-mir-518d-3p ; hsa-mir-518c-3p ; hsa-mir-518b ; hsa-mir-518a-3p ; hsa-mir-3120-5p ; hsa-mir-6872-3p ; hsa-mir-4724-5p ; hsa-mir-4699-3p ; hsa-mir-448 ; hsa-mir-153-3p ; hsa-mir-372-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-6501-3p ; hsa-mir-342-3p ; hsa-mir-603 ; hsa-mir-8485

Nearest miRNA

hsa-mir-1244-3/Upstream/1726020; hsa-let-7i/Downstream/938657;

Nearest TSS

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/8113, chr12-CpG: 138/Downstream/46451

Upstream sequence

ACAGAgaccggccacagtggctcatgcctgtaatcccaacactttggagaatgaggtacaggggatcgcttcagtccaggagtttgagactagcctgggc

Downstream sequence

aatatagtgagacctcgtctctacaaaacatttttaaaaattacaagggcttggtggcgtgtgcctgtggtcccagctacttgggaggctgaggtgggag