Basic Information
VIS ID
TVIS10012874
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
819
Orient
+
Integrated sequence
CACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATCTTGAGTCCCTTTTTACCGCTGTTACCAATTTTCTTTTGT| |CTTTGGGTATACATTTAAACCCTAACAAAACAAAGAGATGGGGTTACTCTCTAAATTTTATGGGTTATGTCATTGGATGTTATGGGTCCTTGCCACAAGA
Host Sequence
Chromosome
chr12
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
60301093/59907312 (Hg38)
End
60301093/59907312 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1228/Upstream/2082620; hsa-let-7i/Downstream/2353047;
Nearest TSS
ENST00000382841/Upstream/138253; ENST00000552378/Downstream/185552;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/310586, chr12-CpG: 117/Downstream/2283675
Nearby gene
SLC16A7(-117458) ; TAFA2(+1800936) ;
Upstream sequence
GGAAAGAAGCAAATGGGAGACTTTTTCTCTGTATGTTGTTTTATTACCTCGAACTTGTTGCAAGGCATATTTTTACTCACTTAAAAGTAAAGGTGCAAGA
Downstream sequence
TACAAGTTAGAAATCTAAAATTCTTCTCATTTGTCATTGGCTTGTAATTGTTAATAGTCCAGAATTTTCTGAGTGTCTGAACCTTTATCTTCCCCTCTCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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