Basic Information
VIS ID
TVIS10012879
Fusion event
HBV-LOC105370202 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2374
Orient
+
Integrated sequence
TGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAA| |GAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGG
Host Sequence
Chromosome
chr13
Cytoband
q14.2
Reference genome
GRCh37/hg19
Start
49171778/48597642 (Hg38)
End
49171778/48597642 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105370202
Nearest miRNA
hsa-mir-2276/Upstream/4401442; hsa-mir-1267/Downstream/1398773;
Nearest TSS
ENST00000623511/Upstream/19554; ENST00000617562/Downstream/56069;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/64315, chr13-CpG: 132/Downstream/378044
Nearby gene
LINC00462(-16741) ; CYSLTR2(+109173) ;
Upstream sequence
atttgagatctgctctcaagaattattcattccctggctatctcccttgtatacatgagatatacatattaataaacttgttttttttctcttattaatt
Downstream sequence
tcggtacaggggtctgtcctaacaaaaaactcagaaaaggtagagaaaaaattattttctcctcccctacacacaaataatggtggtttcttgcttcaca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate