VISDB Viral Integration Site DataBase

VIS ID

TVIS10012882

Fusion event

HBV-AKAP6 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|large S protein|

Start

2876

Orient

+

Integrated sequence

TTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAAT| |CCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAG

Chromosome

chr14

Cytoband

q12

Reference genome

Start

End

32989035/32519829 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-1257 ; hsa-mir-4687-3p ; hsa-mir-7974 ; hsa-mir-583 ; hsa-mir-1276 ; hsa-mir-4311 ; hsa-mir-1303 ; hsa-mir-5096 ; hsa-mir-3187-3p ; hsa-mir-4435 ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-548s ; hsa-mir-7641 ; hsa-mir-197-3p ; hsa-mir-411-5p ; hsa-mir-6832-5p ; hsa-mir-193b-5p ; hsa-mir-4755-3p ; hsa-mir-4695-3p ; hsa-mir-4716-5p ; hsa-mir-4781-3p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-483-5p

Nearest miRNA

hsa-mir-208a/Upstream/1505087; hsa-mir-1185-1/Downstream/4432480;

Nearest TSS

Nearest CpG islands

None/Target, chr14-CpG: 35/Upstream/316120, chr14-CpG: 168/Downstream/413059

Upstream sequence

cccacataataataatgggagactttaacaccccactgtcaacattagacagatcaacgagacagaaagttaacaaggatatccaggaattcaactcagc

Downstream sequence

tctgcaccaagcagacataatagacatctacagaactctccaccccaaatcaacagaatatacattcttctcagcaccacatcacacttattccaaaatt