VISDB Viral Integration Site DataBase

VIS ID

TVIS10012887

Fusion event

HBV-LRRC57 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

432

Orient

+

Integrated sequence

TCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATC| |TTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGA

Chromosome

chr15

Cytoband

q15.2

Reference genome

Start

End

42836544/42544346 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-21-5p ; hsa-mir-877-5p ; hsa-mir-599 ; hsa-mir-3161 ; hsa-mir-668-3p ; hsa-mir-4756-3p ; hsa-mir-3919 ; hsa-mir-100-3p ; hsa-mir-3149 ; hsa-mir-1238-3p ; hsa-mir-670-3p ; hsa-mir-411-5p ; hsa-mir-6832-5p ; hsa-mir-4524a-3p ; hsa-mir-6891-3p ; hsa-mir-6823-5p ; hsa-mir-6072 ; hsa-mir-4524b-3p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p

Nearest miRNA

hsa-mir-1233-1/Upstream/344680; hsa-mir-10393/Downstream/1249313;

Nearest TSS

Nearest CpG islands

None/Target, chr15-CpG: 55/Upstream/53260, chr15-CpG: 68/Downstream/3918

Upstream sequence

ACTGCTGTAAATGCAAAATGAATTACATAGTTTTggccaggtgcagaggctcacacttgcaatctcaacactttgggaggccaaggtaggtggatcgctt

Downstream sequence

gagcctaggagtttcagaccagcctgagcaatctaccaaaaatagaaaaatgaggcatggtagcgcctgtagtctcagctaatcaggaggttgagatggg