Basic Information
VIS ID
TVIS10012893
Fusion event
HBV-LOC105371348 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
3017
Orient
+
Integrated sequence
CAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTC| |ACCCCACCGCACGGAGGCCTTTTGGGGTGGAGCCCTCAGGCTCAGGGCATACTACAAACTTTGCCAGCAAATCCGCCTCCTGCCTCCACCAATCGCCAGT
Host Sequence
Chromosome
chr16
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
75859247/75825349 (Hg38)
End
75859247/75825349 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105371348
Nearest miRNA
hsa-mir-1225/Upstream/5794927; hsa-mir-11401/Downstream/1043587;
Nearest TSS
ENST00000527434/Upstream/98907; ENST00000463177/Downstream/35483;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/176668, chr16-CpG: 18/Downstream/409730
Nearby gene
TERF2IP(-167906) ; CNTNAP4(+451929) ;
Upstream sequence
tttccatgtagttgagcggctttgagtgagattcttaatcctgagttctagtttgattgcactgtggtctgagagacagtttgttataatttctgttctt
Downstream sequence
ttacatttgctgaggagtgctttacttccaactatgtggtcaattttggaataggtgtggtgtggtgctgaaaaaaatgtatattctgttgatttggggt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate