Basic Information
VIS ID
TVIS10012900
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
269
Orient
+
Integrated sequence
CATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTC| |TCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGT
Host Sequence
Chromosome
chr2
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
131043292/130285719 (Hg38)
End
131043292/130285719 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA2S
Nearest miRNA
hsa-mir-1285-2/Upstream/2862101; hsa-mir-10b/Downstream/1205441;
Nearest TSS
ENST00000437798/Upstream/87258; ENST00000470672/Downstream/56416;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/32528, chr2-CpG: 47/Downstream/2708
Nearby gene
TUBA3E(-87258) ; CCDC115(+52524) ;
Upstream sequence
CAAAGGGACCCCCAGGGCTTCCTGGCTTTGGGAGCGATGCTGGAGCCGAGGAAGAGGTGAGTGACAAACACATGGCCAGGTGTGTCTCCCATCACCCTCA
Downstream sequence
GCCCTGAAGCCTGTGGGACTCTGAGGGGCCTGCTCTGCTCCAGGCCCCCAGCCGCCAGGCCCCGGGGTCCCTGCTCAGTGAGGGCCACCCACAGACCCTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate