Basic Information
VIS ID
TVIS10012906
Fusion event
HBV-LOC105374465 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2876
Orient
+
Integrated sequence
TTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAAT| |CCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAG
Host Sequence
Chromosome
chr2
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
37952913/37725770 (Hg38)
End
37952913/37725770 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105374465
Nearest miRNA
hsa-mir-1301/Upstream/2254284; hsa-mir-10b/Downstream/9651905;
Nearest TSS
ENST00000437798/Upstream/36921; ENST00000431712/Downstream/12698;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/53083, chr2-CpG: 79/Downstream/199261
Nearby gene
CDC42EP3(-53235) ; RMDN2(+199549) ;
Upstream sequence
cccacacaataataatgggagactttaacaccccactgtcaacattagacagatcaatgagacagaaagttaacaaggatatccaggaattgaattcagc
Downstream sequence
tctgcaccaagcagacataatagacatctacagaactctccaccccaaatgaacagaatatacattcttctcagcaccacaccacacctattccaaaact
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate