Basic Information
VIS ID
TVIS10012907
Fusion event
HBV-LOC105369168 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2876
Orient
+
Integrated sequence
TTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAAT| |CCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAG
Host Sequence
Chromosome
chr2
Cytoband
p14
Reference genome
GRCh37/hg19
Start
66154852/65927718 (Hg38)
End
66154852/65927718 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
LOC105369168
Nearest miRNA
hsa-mir-1301/Upstream/1402153; hsa-mir-10b/Downstream/430531;
Nearest TSS
ENST00000437798/Upstream/287541; ENST00000412313/Downstream/308495;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/490973, chr2-CpG: 102/Downstream/498018
Nearby gene
SPRED2(-495196) ; MIR4778(+430529) ;
Upstream sequence
ttttggaataggggtggtgtggtgctgaaaagaatgtatattctgttgatttggggtggagagttctgtagatgtctattatgtctgcttggtgcagagc
Downstream sequence
tgagttcaattcctgggtatccttgttaactttctgtctcgttgatctgtctaatgttgacagtggggtgttaaagtctcccattattaatgtgtgggag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate