VISDB Viral Integration Site DataBase

VIS ID

TVIS10012908

Fusion event

HBV-ALMS1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

2122

Orient

+

Integrated sequence

GCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTG| |TTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTG

Chromosome

chr2

Cytoband

p13.1

Reference genome

Start

End

73665386/73438258 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

FRA2S ; FRA2E

Target gene

miRNAs that regulate target gene

hsa-mir-197-3p ; hsa-mir-375 ; hsa-mir-21-5p ; hsa-mir-99b-3p ; hsa-mir-92a-3p ; hsa-mir-22-3p ; hsa-mir-218-5p

Nearest miRNA

hsa-mir-1285-2/Upstream/3185253; hsa-mir-10b/Downstream/1652554;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/51725, chr2-CpG: 31/Downstream/298933

Upstream sequence

cctcatcaatagggtgaagaggaggcaaAAGAAAGAAATATTTGTGTCCATGTTTGATTCATATTGTATTGAAATGGTCCCTTGATATTAGTTGCCCTGA

Downstream sequence

TTTCTTATTTTTTTATTGGCAAACCTCTGGGTCCTATTTTATAACAAGCAGAAAGTAACTGCCAAGCTTCATTTCAAATTGGCTCCAAAGTATGAGTCAA