Basic Information
VIS ID
TVIS10012912
Fusion event
HBV-chr20 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2921
Orient
+
Integrated sequence
CCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGA| |GCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCACCC
Host Sequence
Chromosome
chr20
Cytoband
p11.21
Reference genome
GRCh37/hg19
Start
22971576/22990939 (Hg38)
End
22971576/22990939 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-103a-2/Upstream/4520248; hsa-mir-1-1/Downstream/3217247;
Nearest TSS
ENST00000382410/Upstream/305475; ENST00000255008/Downstream/39846;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/403697, chr20-CpG: 117/Downstream/44140
Nearby gene
FOXA2(-405475) ; SSTR4(+44481) ;
Nearest cancer related gene
FOXA2(TSG, -405475) ;
Upstream sequence
tcattatgtacctagcagtcattcaggagcaggttattcagtttccatgtagttgagcggtttgagtgagtttcttaatcctgagttctagtttgattac
Downstream sequence
actgtggtctgagagacagtttgttataatttctgttcttttacatttgctgaggagtgctttacttccaactatgtggtcaattttggaataggtgtgg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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